Shiitake Mushroom (Lentinula edodes)

Shiitake is prized for many reasons. In fact, researchers in Japan developed an extract known as Lentinan from shiitake mushrooms. Lentinan has been shown to be a helpful part of cancer therapies.  In addition to these health benefits, shiitake is a good source of amino acids and a number of vitamins and minerals. Thanks to all these healthy factors, shiitake is the second most commonly cultivated mushroom in the world.



Yang, Hyun, Inho Hwang, Sun Kim, Changhwan Ahn, Eui-Ju Hong, and Eui-Bae Jeung. Preventive effects of Lentinus edodes on homocysteinemia in mice. Exp Ther Med. 2013 Aug; 6(2): 465–468.

Yu, Sanhong, Veronika Weaver, Keith Martin, and Margherita T Cantorna, corresponding author. The effects of whole mushrooms during inflammation. BMC Immunol. 2009; 10: 12.

Yang, Hyun, Inho Hwang, Sun Kim, Eui-Ju Hong, and Eui-Bae Jeung. Lentinus edodes promotes fat removal in hypercholesterolemic mice. Exp Ther Med. 2013 Dec; 6(6): 1409–1413.




Handayani, Dian, et al. A High-Dose Shiitake Mushroom Increases Hepatic Accumulation of Triacylglycerol in Rats Fed a High-Fat Diet: Underlying Mechanism. Nutrients. 2014 Feb; 6(2): 650–662.

Vetvicka, Vaclav, corresponding author, and Jana Vetvickova. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb; 2(2): 14.

Saif, Ashraf, corresponding author, Kristian Wende, and Ulrike Lindequist. In vitro bone inducing effects of Lentinula edodes (shiitake) water extract on human osteoblastic cell cultures. Nat Prod Bioprospect. 2013 Dec; 3(6): 282–287.

Rincão, Vinicius Pires, et al. Polysaccharide and extracts from Lentinula edodes: structural features and antiviral activity. Virol J. 2012; 9: 37.