Jing-jie (Schizonepeta tenuifolia)

Jing-jie is the Chinese name for Schizonepeta tenuifolia, also known as Japanese catnip. It is a medicinal herb frequently used clinically for the treatment of the common cold and nettle rash. Jing-jie contains several chemical compounds, including menthol, menthone, cineole, hesperidin, caffeic acid and schizonodiol. Typically, schizonepeta is used to treat symptoms such as headaches, chills, and fever. It also helps to treat bloody stools and uterine bleeding; studies of schizonepeta extract suggest it can speed up the time it takes for blood to clot. Schizonepeta can also reduce inflammation and swelling.
 

Min-Hee Kim, Jaewoong Son, Hae Jeong Nam, Seong-Gyu Ko, Inhwa Choi. Hyeonggaeyeongyo-Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre-Post Study. Evid Based Complement Alternat Med. 2016; 2016: 9202675. Published online 2016 Sep 6. doi: 10.1155/2016/9202675.

Sheng Yu, Yiwen Chen, Li Zhang, Mingqiu Shan, Yuping Tang, Anwei Ding.  Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times. Int J Mol Sci. 2011; 12(10): 6635–6644. Published online 2011 Oct 10. doi: 10.3390/ijms12106635

Tao Yu, Yong Jun Li, Ai Hong Bian, Hui Bin Zuo, Ti Wen Zhu, Sheng Xiang Ji, Fanming Kong, De Qing Yin, Chuan Bao Wang, Zi Fu Wang, Hong Qun Wang, Yanyan Yang, Byong Chul Yoo, Jae Youl Cho. The Regulatory Role of Activating Transcription Factor 2 in Inflammation. Mediators Inflamm. 2014; 2014: 950472. Published online 2014 Jun 23. doi: 10.1155/2014/950472.

Won Choi, Jee Bum Lee, Lian Cui, Ying Li, Zhengri Li, Ji Suk Choi, Hyo Seok Lee, Kyung Chul Yoon. Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye. Oxid Med Cell Longev. 2016; 2016: 4727415. Published online 2016 May 26. doi: 10.1155/2016/4727415.

Ying-Ju Lin, Tsung-Jung Ho, Ting-Hsu Lin, Wei-Yi Hsu, Shao-Mei Huang, Chiu-Chu Liao, Chih-Ho Lai, Xiang Liu, Hsinyi Tsang, Chien-Chen Lai, Fuu-Jen Tsai. P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions. Biomedicine (Taipei) 2015 Jun; 5(2): 10. Published online 2015 Jun 6. doi: 10.7603/s40681-015-0010-0.

 

 

Beihua Bao, Ting Geng, Yudan Cao, Weifeng Yao, Li Zhang, Anwei Ding. Effects of Schizonepetin on Activity and mRNA Expression of Cytochrome P450 Enzymes in Rats. Int J Mol Sci. 2012; 13(12): 17006–17018. Published online 2012 Dec 12. doi: 10.3390/ijms131217006.

Beihua Bao, Zheng Meng, Nianguang Li, Zhengjie Meng, Li Zhang, Yudan Cao, Weifeng Yao, Mingqiu Shan, Anwei Ding. Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives. Int J Mol Sci. 2013 Aug; 14(8): 17193–17203. Published online 2013 Aug 20. doi: 10.3390/ijms140817193.

Bor-Sen Wang, Guan-Jhong Huand, Huo-Mu Tai, Ming-Hsing Huang. Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq. Food and Chemical Toxicology Volume 50, Issues 3–4, March–April 2012, Pages 526–531.

Do Young Kwon, Sun Ju Kim, Ju Won Lee, Young Chul Kim. Comparison of Hydroxyl Radical, Peroxyl Radical, and Peroxynitrite Scavenging Capacity of Extracts and Active Components from Selected Medicinal Plants. Toxicol Res. 2010 Dec; 26(4): 321–327. doi: 10.5487/TR.2010.26.4.321.

Jong Hee Choi, Min Jung Lee, Minhee Jang, Eun-Jeong Kim, Insop Shim, Hak-Jae Kim, Sanghyun Lee, Sang Won Lee, Young Ock Kim, Ik-Hyun Cho. An Oriental Medicine, Hyungbangpaedok-San Attenuates Motor Paralysis in an Experimental Model of Multiple Sclerosis by Regulating the T Cell Response. PLoS One. 2015; 10(10): e0138592. Published online 2015 Oct 7. doi: 10.1371/journal.pone.0138592. Correction in: PLoS One. 2015; 10(10): e0141635.

Ju-Young Kim, Jong Min Baek, Sung-Jun Ahn, Yoon-Hee Cheon, Sun-Hyang Park, Miyoung Yang, Min Kyu Choi, Jaemin Oh. Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide-induced bone loss in vivo. BMC Complement Altern Med. 2016; 16(1): 301. Published online 2016 Aug 22. doi: 10.1186/s12906-016-1300-0.