Cordyceps (Cordyceps sinensis)

Cordyceps sinensis mycelia

Cordyceps sinensis mycelia, also known as dong cong xia cao (winter worm, summer grass), contains many active ingredients - Cordycepin, cordycepic acids, polysaccharides, adenosine, amino acids and ergosterol. The synergistic effects of these components make Cordyceps sinensis a potent mushroom with positive effects on the heart, lungs and kidneys. It also increases the amount of powerful antioxidant enzymes in the body. In addition it can significantly elevate the function of cells contributing to immune system functions, thus helping protect the body.


 

Xia Liu, Fang Zhong, Xu-long Tang, Fu-lin Lian, Qiao Zhou, Shan-mai Guo, Jia-fu Liu, Peng Sun, Xu Hao, Ying Lu, Wei-ming Wang, Nan Chen, Nai-xia Zhang. Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis. Acta Pharmacol Sin. 2014 May; 35(5): 697–706. Published online 2014 Mar 17. doi: 10.1038/aps.2013.186.

Yi Liu, Jihui Wang, Wei Wang, Hanyue Zhang, Xuelan Zhang, Chunchao Han. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evid Based Complement Alternat Med. 2015; 2015: 575063. Published online 2015 Apr 16. doi: 10.1155/2015/575063.

Yingxin Zou, Yuxiang Liu, Minghua Ruan, Xu Feng, Jiachun Wang, Zhiyong Chu, Zesheng Zhang. Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. Int J Mol Med. 2015 Oct; 36(4): 939–946. Published online 2015 Jul 30. doi: 10.3892/ijmm.2015.2296.

You-you Gu, Huan Wang, Su Wang, Hua Gao, Ming-cai Qiu. Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats. Evid Based Complement Alternat Med. 2015; 2015: 369631. Published online 2015 Dec 2.

Yuan Dong, Tianjiao Jing, Qingfan Meng, Chungang Liu, Shuang Hu, Yihang Ma, Yan Liu, Jiahui Lu, Yingkun Cheng, Di Wang, Lirong Teng. Studies on the Antidiabetic Activities of Cordyceps militaris Extract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats. Biomed Res Int. 2014; 2014: 160980. Published online 2014 Mar 11. doi: 10.1155/2014/160980.

Yuan Peng, Kai Huang, Li Shen, Yan-yan Tao, Cheng-hai Liu. Cultured Mycelium Cordyceps sinensis alleviates CCI4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells. Acta Pharmacol Sin. 2016 Feb; 37(2): 204–216. Published online 2015 Nov 23. doi: 10.1038/aps.2015.129

Yuan Peng, Qian Chen, Tao Yang, Yanyan Tao, Xiong Lu, Chenghai Liu. Cultured mycelium Cordyceps sinensis protects liver sinusoidal endothelial cells in acute liver injured mice. Mol Biol Rep. 2014; 41(3): 1815–1827. Published online 2014 Jan 19. doi: 10.1007/s11033-014-3031-y.

Yuan Peng, Yanyan Tao, Qinglan Wang, Li Shen, Tao Yang, Zulong Liu, Chenghai Liu. Ergosterol Is the Active Compound of Cultured Mycelium Cordyceps sinensis on Antiliver Fibrosis. Evid Based Complement Alternat Med. 2014; 2014: 537234. Published online 2014 Oct 15. doi: 10.1155/2014/537234.

Zhenquan Liu, Pengtao Li, Dan Zhao, Huiling Tang, Jianyou Guo. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Behav Brain Funct. 2010; 6: 61. Published online 2010 Oct 19. doi: 10.1186/1744-9081-6-61.

 

 

 

Ailing Liu, Jinxiang Wu, Aijun Li, Wenxiang Bi, Tian Liu, Liuzhao Cao, Yahui Liu, Liang Dong. The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells. Int J Chron Obstruct Pulmon Dis. 2016; 11: 1721–1731. Published online 2016 Jul 28. doi: 10.2147/COPD.S107396.

Da-wei Zhang, Zhen-lin Wang, Wei Qi, Guang-yue Zhao. The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in Ovariectomized rats. BMC Complement Altern Med. 2014; 14: 484. Published online 2014 Dec 13. doi: 10.1186/1472-6882-14-484.

Feng Du, Si Li, Tian Wang, Hai-Yan Zhang, Zhi-Hong Zong, Zhen-Xian Du, De-Tian Li, Hua-Qin Wang, Bo Liu, Jia-Ning Miao, Xiao-Hui Bian. Cordyceps sinensis attenuates renal brosis and suppresses BAG3 induction in obstructed rat kidney. Am J Transl Res. 2015; 7(5): 932–940. Published online 2015 May 15.

Guo-Sheng Gu, Jian-An Ren, Guan-Wei Li, Yu-Jie Yuan, Ning Li, Jie-Shou Li. Cordyceps sinensis preserves intestinal mucosal barrier and may be an adjunct therapy in endotoxin-induced sepsis rat model: a pilot study. Int J Clin Exp Med. 2015; 8(5): 7333–7341. Published online 2015 May 15.

Hardeep S. Tuli, Sardul S. Sandhu, A. K. Sharma. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014 Feb; 4(1): 1–12. Published online 2013 Feb 19. doi: 10.1007/s13205-013-0121-9.

Jian-You Guo, Chun-Chao Han, Yong-Mei Liu. A Contemporary Treatment Approach to Both Diabetes and Depression by Cordyceps sinensis, Rich in Vanadium. Evid Based Complement Alternat Med. 2010 Sep; 7(3): 387–389. Published online 2009 Nov 30. doi: 10.1093/ecam/nep201.

K. P. Singh, H. S. Meena, P. S. Negi. Enhancement of Neuromuscular Activity by Natural Specimens and Cultured Mycelia of Cordyceps sinensis in Mice. Indian J Pharm Sci. 2014 Sep-Oct; 76(5): 458–461.

Kanitta Jiraungkoorskul, Wannee Jiraungkoorskul. Review of Naturopathy of Medical Mushroom, Ophiocordyceps Sinensis, in Sexual Dysfunction. Pharmacogn Rev. 2016 Jan-Jun; 10(19): 1–5. doi: 10.4103/0973-7847.176566.

Mrinalini Singh, Rajkumar Tulsawani, Praveen Koganti, Amitabh Chauhan, Manimaran Manickam, Kshipra Misra. Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells. Biomed Res Int. 2013; 2013: 569206. Published online 2013 Aug 26. doi: 10.1155/2013/569206.

Wei-Chih Kan, Hsien-Yi Wang, Chih-Chiang Chien, Shun-Lai Li, Yu-Chun Chen, Liang-Hao Chang, Chia-Hui Cheng, Wan-Chen Tsai, Jyh-Chang Hwang, Shih-Bin Su, Li-Hsueh Huang, Jiunn-Jye Chuu. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evid Based Complement Alternat Med. 2012; 2012: 743107. Published online 2012 Feb 29. doi: 10.1155/2012/743107.